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multidrug resistant mrsa strain staphylococcus aureus atcc baa  (ATCC)


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    Structured Review

    ATCC multidrug resistant mrsa strain staphylococcus aureus atcc baa
    Multidrug Resistant Mrsa Strain Staphylococcus Aureus Atcc Baa, supplied by ATCC, used in various techniques. Bioz Stars score: 95/100, based on 88 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/multidrug+resistant+mrsa+strain/Staphylococcus+aureus+subsp%2E+aureus+Rosenbach/pm39722003-294-18-24
    Average 95 stars, based on 88 article reviews
    multidrug resistant mrsa strain staphylococcus aureus atcc baa - by Bioz Stars, 2026-09
    95/100 stars

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    Related Articles

    Irradiation:

    Article Title: Photoactivated 2,3-Distyrylindoles Kill Multi-Drug Resistant Bacteria
    Article Snippet: To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.. 28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.. 28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.

    Article Title: Photoactivated 2,3-Distyrylindoles Kill Multi-Drug Resistant Bacteria
    Article Snippet: Herein, we describe these recent findings by showing that 1 and its structural analogues represent significant promise as light-activated antimicrobial agents active against resistant Gram-positive and Gram-negative strains, including those that pose the greatest risk to human health as identified by the WHO, as discussed above. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Previously synthesized 2,3-distyrylindole 1 .significant promise as light-activated antimicrobial agents active against resistant Gram-positive and Gram-negative strains, including those that pose the greatest risk to human health as identified by the WHO, as discussed above. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Previously synthesized 2,3-distyrylindole 1 . ... Our initial experimentation involved the utilization of a multidrug resistant MRSA strain (ATCC BAA-44, HA-MRSA), a clinical isolate from a hospital in Lisbon, Portugal.. In addition to beta-lactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.In addition to beta-lactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.

    Article Title: Photoactivated 2,3-Distyrylindoles Kill Multi-Drug Resistant Bacteria
    Article Snippet: To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.. The panel included: another multidrug-resistant MRSA strain (ATCC BAA1717, CA-MRSA); drug-sensitive Staphylococcus aureus ; vancomycin-resistant Enterococcus faecalis , known as VRE and representing another bacterial genus on the WHO list as discussed above; 26 Streptococcus pyogenes , a causative agent of important human diseases, ranging from superficial skin infections to life-threatening systemic infections; 27 Streptococcus mutans , a species commonly found in human oral cavity and the main contributor to tooth decay.. 28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into..

    Article Title: Photoactivated 2,3-distyrylindoles kill multi-drug resistant bacteria
    Article Snippet: To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA44), we performed experiments with other Gram-positive bacterial strains.not limited to HA-MRSA (ATCC BAA44), we performed experiments with other Gram-positive bacterial strains. ... The panel included: another multidrug-resistant MRSA strain (ATCC BAA1717, CA-MRSA); drug-sensitive Staphylococcus aureus; vancomycin-resistant Enterococcus faecalis, known as VRE and representing another bacterial genus on the WHO list as discussed above;26 Streptococcus pyogenes, a causative agent of important human diseases, ranging from superficial skin infections to life-threatening systemic infections;27 Streptococcus mutans, a species commonly found in human oral cavity and the main contributor to tooth decay.28 The latter organism is of particular interest due to its resistance to various classes of antibiotics29 and the convenience of light delivery into the oral cavity.. As can be seen in Figure 4, all these Gram-positive organisms are sensitive to the bactericidal effects of 1.As can be seen in Figure 4, all these Gram-positive organisms are sensitive to..

    Article Title: Photoactivated 2,3-distyrylindoles kill multi-drug resistant bacteria
    Article Snippet: Previously synthesized 2,3-distyrylindole 1.Previously synthesized 2,3-distyrylindole 1.. Our initial experimentation involved the utilization of a multidrug resistant MRSA strain (ATCC BAA-44, HA-MRSA), a clinical isolate from a hospital in Lisbon, Portugal.. In addition to betalactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.23,24 Thus, the bacterial isolates (ca.In addition to betalactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.23,24 Thus, the bacterial isolates (ca.

    Article Title: Bio-inspired synthesis yields a tricyclic indoline that selectively resensitizes methicillin-resistant Staphylococcus aureus (MRSA) to ?-lactam antibiotics
    Article Snippet: With this highly diverse and functionalized indoline library in hand, we next screened their ability to potentiate the activity of methicillin in MRSA.With this highly diverse and functionalized indoline library in hand, we next screened their ability to potentiate the activity of methicillin in MRSA.. A multidrug-resistant MRSA strain [American Type Culture Collection (ATCC): BAA-44] was selected for the initial screening.. In addition to methicillin, this MRSA strain is also resistant to many other β-lactam antibiotics, as well as antibiotics from other structural classes, such as erythromycin, tetracycline, and ciprofloxacin.In addition to methicillin, this MRSA strain is also resistant to many other β-lactam antibiotics, as well as antibiotics from other structural classes, such as erythromycin, tetracycline, and ciprofloxacin.

    Derivative Assay:

    Article Title: Photoactivated 2,3-Distyrylindoles Kill Multi-Drug Resistant Bacteria
    Article Snippet: To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.. 28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.. 28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.

    Article Title: Photoactivated 2,3-Distyrylindoles Kill Multi-Drug Resistant Bacteria
    Article Snippet: Herein, we describe these recent findings by showing that 1 and its structural analogues represent significant promise as light-activated antimicrobial agents active against resistant Gram-positive and Gram-negative strains, including those that pose the greatest risk to human health as identified by the WHO, as discussed above. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Previously synthesized 2,3-distyrylindole 1 .significant promise as light-activated antimicrobial agents active against resistant Gram-positive and Gram-negative strains, including those that pose the greatest risk to human health as identified by the WHO, as discussed above. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Previously synthesized 2,3-distyrylindole 1 . ... Our initial experimentation involved the utilization of a multidrug resistant MRSA strain (ATCC BAA-44, HA-MRSA), a clinical isolate from a hospital in Lisbon, Portugal.. In addition to beta-lactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.In addition to beta-lactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.

    Article Title: Photoactivated 2,3-Distyrylindoles Kill Multi-Drug Resistant Bacteria
    Article Snippet: To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.. The panel included: another multidrug-resistant MRSA strain (ATCC BAA1717, CA-MRSA); drug-sensitive Staphylococcus aureus ; vancomycin-resistant Enterococcus faecalis , known as VRE and representing another bacterial genus on the WHO list as discussed above; 26 Streptococcus pyogenes , a causative agent of important human diseases, ranging from superficial skin infections to life-threatening systemic infections; 27 Streptococcus mutans , a species commonly found in human oral cavity and the main contributor to tooth decay.. 28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into..

    Article Title: Photoactivated 2,3-distyrylindoles kill multi-drug resistant bacteria
    Article Snippet: To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA44), we performed experiments with other Gram-positive bacterial strains.not limited to HA-MRSA (ATCC BAA44), we performed experiments with other Gram-positive bacterial strains. ... The panel included: another multidrug-resistant MRSA strain (ATCC BAA1717, CA-MRSA); drug-sensitive Staphylococcus aureus; vancomycin-resistant Enterococcus faecalis, known as VRE and representing another bacterial genus on the WHO list as discussed above;26 Streptococcus pyogenes, a causative agent of important human diseases, ranging from superficial skin infections to life-threatening systemic infections;27 Streptococcus mutans, a species commonly found in human oral cavity and the main contributor to tooth decay.28 The latter organism is of particular interest due to its resistance to various classes of antibiotics29 and the convenience of light delivery into the oral cavity.. As can be seen in Figure 4, all these Gram-positive organisms are sensitive to the bactericidal effects of 1.As can be seen in Figure 4, all these Gram-positive organisms are sensitive to..

    Article Title: Photoactivated 2,3-distyrylindoles kill multi-drug resistant bacteria
    Article Snippet: Previously synthesized 2,3-distyrylindole 1.Previously synthesized 2,3-distyrylindole 1.. Our initial experimentation involved the utilization of a multidrug resistant MRSA strain (ATCC BAA-44, HA-MRSA), a clinical isolate from a hospital in Lisbon, Portugal.. In addition to betalactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.23,24 Thus, the bacterial isolates (ca.In addition to betalactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.23,24 Thus, the bacterial isolates (ca.

    Article Title: Bio-inspired synthesis yields a tricyclic indoline that selectively resensitizes methicillin-resistant Staphylococcus aureus (MRSA) to ?-lactam antibiotics
    Article Snippet: With this highly diverse and functionalized indoline library in hand, we next screened their ability to potentiate the activity of methicillin in MRSA.With this highly diverse and functionalized indoline library in hand, we next screened their ability to potentiate the activity of methicillin in MRSA.. A multidrug-resistant MRSA strain [American Type Culture Collection (ATCC): BAA-44] was selected for the initial screening.. In addition to methicillin, this MRSA strain is also resistant to many other β-lactam antibiotics, as well as antibiotics from other structural classes, such as erythromycin, tetracycline, and ciprofloxacin.In addition to methicillin, this MRSA strain is also resistant to many other β-lactam antibiotics, as well as antibiotics from other structural classes, such as erythromycin, tetracycline, and ciprofloxacin.

    Incubation:

    Article Title: Photoactivated 2,3-Distyrylindoles Kill Multi-Drug Resistant Bacteria
    Article Snippet: To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.. 28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.. 28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.

    Article Title: Photoactivated 2,3-Distyrylindoles Kill Multi-Drug Resistant Bacteria
    Article Snippet: Herein, we describe these recent findings by showing that 1 and its structural analogues represent significant promise as light-activated antimicrobial agents active against resistant Gram-positive and Gram-negative strains, including those that pose the greatest risk to human health as identified by the WHO, as discussed above. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Previously synthesized 2,3-distyrylindole 1 .significant promise as light-activated antimicrobial agents active against resistant Gram-positive and Gram-negative strains, including those that pose the greatest risk to human health as identified by the WHO, as discussed above. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Previously synthesized 2,3-distyrylindole 1 . ... Our initial experimentation involved the utilization of a multidrug resistant MRSA strain (ATCC BAA-44, HA-MRSA), a clinical isolate from a hospital in Lisbon, Portugal.. In addition to beta-lactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.In addition to beta-lactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.

    Article Title: Photoactivated 2,3-Distyrylindoles Kill Multi-Drug Resistant Bacteria
    Article Snippet: To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.. The panel included: another multidrug-resistant MRSA strain (ATCC BAA1717, CA-MRSA); drug-sensitive Staphylococcus aureus ; vancomycin-resistant Enterococcus faecalis , known as VRE and representing another bacterial genus on the WHO list as discussed above; 26 Streptococcus pyogenes , a causative agent of important human diseases, ranging from superficial skin infections to life-threatening systemic infections; 27 Streptococcus mutans , a species commonly found in human oral cavity and the main contributor to tooth decay.. 28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into..

    Article Title: Photoactivated 2,3-distyrylindoles kill multi-drug resistant bacteria
    Article Snippet: To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA44), we performed experiments with other Gram-positive bacterial strains.not limited to HA-MRSA (ATCC BAA44), we performed experiments with other Gram-positive bacterial strains. ... The panel included: another multidrug-resistant MRSA strain (ATCC BAA1717, CA-MRSA); drug-sensitive Staphylococcus aureus; vancomycin-resistant Enterococcus faecalis, known as VRE and representing another bacterial genus on the WHO list as discussed above;26 Streptococcus pyogenes, a causative agent of important human diseases, ranging from superficial skin infections to life-threatening systemic infections;27 Streptococcus mutans, a species commonly found in human oral cavity and the main contributor to tooth decay.28 The latter organism is of particular interest due to its resistance to various classes of antibiotics29 and the convenience of light delivery into the oral cavity.. As can be seen in Figure 4, all these Gram-positive organisms are sensitive to the bactericidal effects of 1.As can be seen in Figure 4, all these Gram-positive organisms are sensitive to..

    Article Title: Photoactivated 2,3-distyrylindoles kill multi-drug resistant bacteria
    Article Snippet: Previously synthesized 2,3-distyrylindole 1.Previously synthesized 2,3-distyrylindole 1.. Our initial experimentation involved the utilization of a multidrug resistant MRSA strain (ATCC BAA-44, HA-MRSA), a clinical isolate from a hospital in Lisbon, Portugal.. In addition to betalactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.23,24 Thus, the bacterial isolates (ca.In addition to betalactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.23,24 Thus, the bacterial isolates (ca.

    Article Title: Bio-inspired synthesis yields a tricyclic indoline that selectively resensitizes methicillin-resistant Staphylococcus aureus (MRSA) to ?-lactam antibiotics
    Article Snippet: With this highly diverse and functionalized indoline library in hand, we next screened their ability to potentiate the activity of methicillin in MRSA.With this highly diverse and functionalized indoline library in hand, we next screened their ability to potentiate the activity of methicillin in MRSA.. A multidrug-resistant MRSA strain [American Type Culture Collection (ATCC): BAA-44] was selected for the initial screening.. In addition to methicillin, this MRSA strain is also resistant to many other β-lactam antibiotics, as well as antibiotics from other structural classes, such as erythromycin, tetracycline, and ciprofloxacin.In addition to methicillin, this MRSA strain is also resistant to many other β-lactam antibiotics, as well as antibiotics from other structural classes, such as erythromycin, tetracycline, and ciprofloxacin.

    Analogues:

    Article Title: Photoactivated 2,3-Distyrylindoles Kill Multi-Drug Resistant Bacteria
    Article Snippet: To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.. 28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.. 28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.

    Article Title: Photoactivated 2,3-Distyrylindoles Kill Multi-Drug Resistant Bacteria
    Article Snippet: Herein, we describe these recent findings by showing that 1 and its structural analogues represent significant promise as light-activated antimicrobial agents active against resistant Gram-positive and Gram-negative strains, including those that pose the greatest risk to human health as identified by the WHO, as discussed above. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Previously synthesized 2,3-distyrylindole 1 .significant promise as light-activated antimicrobial agents active against resistant Gram-positive and Gram-negative strains, including those that pose the greatest risk to human health as identified by the WHO, as discussed above. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Previously synthesized 2,3-distyrylindole 1 . ... Our initial experimentation involved the utilization of a multidrug resistant MRSA strain (ATCC BAA-44, HA-MRSA), a clinical isolate from a hospital in Lisbon, Portugal.. In addition to beta-lactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.In addition to beta-lactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.

    Article Title: Photoactivated 2,3-Distyrylindoles Kill Multi-Drug Resistant Bacteria
    Article Snippet: To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.. The panel included: another multidrug-resistant MRSA strain (ATCC BAA1717, CA-MRSA); drug-sensitive Staphylococcus aureus ; vancomycin-resistant Enterococcus faecalis , known as VRE and representing another bacterial genus on the WHO list as discussed above; 26 Streptococcus pyogenes , a causative agent of important human diseases, ranging from superficial skin infections to life-threatening systemic infections; 27 Streptococcus mutans , a species commonly found in human oral cavity and the main contributor to tooth decay.. 28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into..

    Article Title: Photoactivated 2,3-distyrylindoles kill multi-drug resistant bacteria
    Article Snippet: To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA44), we performed experiments with other Gram-positive bacterial strains.not limited to HA-MRSA (ATCC BAA44), we performed experiments with other Gram-positive bacterial strains. ... The panel included: another multidrug-resistant MRSA strain (ATCC BAA1717, CA-MRSA); drug-sensitive Staphylococcus aureus; vancomycin-resistant Enterococcus faecalis, known as VRE and representing another bacterial genus on the WHO list as discussed above;26 Streptococcus pyogenes, a causative agent of important human diseases, ranging from superficial skin infections to life-threatening systemic infections;27 Streptococcus mutans, a species commonly found in human oral cavity and the main contributor to tooth decay.28 The latter organism is of particular interest due to its resistance to various classes of antibiotics29 and the convenience of light delivery into the oral cavity.. As can be seen in Figure 4, all these Gram-positive organisms are sensitive to the bactericidal effects of 1.As can be seen in Figure 4, all these Gram-positive organisms are sensitive to..

    Article Title: Photoactivated 2,3-distyrylindoles kill multi-drug resistant bacteria
    Article Snippet: Previously synthesized 2,3-distyrylindole 1.Previously synthesized 2,3-distyrylindole 1.. Our initial experimentation involved the utilization of a multidrug resistant MRSA strain (ATCC BAA-44, HA-MRSA), a clinical isolate from a hospital in Lisbon, Portugal.. In addition to betalactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.23,24 Thus, the bacterial isolates (ca.In addition to betalactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.23,24 Thus, the bacterial isolates (ca.

    Article Title: Bio-inspired synthesis yields a tricyclic indoline that selectively resensitizes methicillin-resistant Staphylococcus aureus (MRSA) to ?-lactam antibiotics
    Article Snippet: With this highly diverse and functionalized indoline library in hand, we next screened their ability to potentiate the activity of methicillin in MRSA.With this highly diverse and functionalized indoline library in hand, we next screened their ability to potentiate the activity of methicillin in MRSA.. A multidrug-resistant MRSA strain [American Type Culture Collection (ATCC): BAA-44] was selected for the initial screening.. In addition to methicillin, this MRSA strain is also resistant to many other β-lactam antibiotics, as well as antibiotics from other structural classes, such as erythromycin, tetracycline, and ciprofloxacin.In addition to methicillin, this MRSA strain is also resistant to many other β-lactam antibiotics, as well as antibiotics from other structural classes, such as erythromycin, tetracycline, and ciprofloxacin.

    Permeability:

    Article Title: Photoactivated 2,3-Distyrylindoles Kill Multi-Drug Resistant Bacteria
    Article Snippet: To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.. 28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.. 28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.

    Article Title: Photoactivated 2,3-Distyrylindoles Kill Multi-Drug Resistant Bacteria
    Article Snippet: Herein, we describe these recent findings by showing that 1 and its structural analogues represent significant promise as light-activated antimicrobial agents active against resistant Gram-positive and Gram-negative strains, including those that pose the greatest risk to human health as identified by the WHO, as discussed above. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Previously synthesized 2,3-distyrylindole 1 .significant promise as light-activated antimicrobial agents active against resistant Gram-positive and Gram-negative strains, including those that pose the greatest risk to human health as identified by the WHO, as discussed above. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Previously synthesized 2,3-distyrylindole 1 . ... Our initial experimentation involved the utilization of a multidrug resistant MRSA strain (ATCC BAA-44, HA-MRSA), a clinical isolate from a hospital in Lisbon, Portugal.. In addition to beta-lactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.In addition to beta-lactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.

    Article Title: Photoactivated 2,3-Distyrylindoles Kill Multi-Drug Resistant Bacteria
    Article Snippet: To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.. The panel included: another multidrug-resistant MRSA strain (ATCC BAA1717, CA-MRSA); drug-sensitive Staphylococcus aureus ; vancomycin-resistant Enterococcus faecalis , known as VRE and representing another bacterial genus on the WHO list as discussed above; 26 Streptococcus pyogenes , a causative agent of important human diseases, ranging from superficial skin infections to life-threatening systemic infections; 27 Streptococcus mutans , a species commonly found in human oral cavity and the main contributor to tooth decay.. 28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into..

    Article Title: Photoactivated 2,3-distyrylindoles kill multi-drug resistant bacteria
    Article Snippet: To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA44), we performed experiments with other Gram-positive bacterial strains.not limited to HA-MRSA (ATCC BAA44), we performed experiments with other Gram-positive bacterial strains. ... The panel included: another multidrug-resistant MRSA strain (ATCC BAA1717, CA-MRSA); drug-sensitive Staphylococcus aureus; vancomycin-resistant Enterococcus faecalis, known as VRE and representing another bacterial genus on the WHO list as discussed above;26 Streptococcus pyogenes, a causative agent of important human diseases, ranging from superficial skin infections to life-threatening systemic infections;27 Streptococcus mutans, a species commonly found in human oral cavity and the main contributor to tooth decay.28 The latter organism is of particular interest due to its resistance to various classes of antibiotics29 and the convenience of light delivery into the oral cavity.. As can be seen in Figure 4, all these Gram-positive organisms are sensitive to the bactericidal effects of 1.As can be seen in Figure 4, all these Gram-positive organisms are sensitive to..

    Article Title: Photoactivated 2,3-distyrylindoles kill multi-drug resistant bacteria
    Article Snippet: Previously synthesized 2,3-distyrylindole 1.Previously synthesized 2,3-distyrylindole 1.. Our initial experimentation involved the utilization of a multidrug resistant MRSA strain (ATCC BAA-44, HA-MRSA), a clinical isolate from a hospital in Lisbon, Portugal.. In addition to betalactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.23,24 Thus, the bacterial isolates (ca.In addition to betalactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.23,24 Thus, the bacterial isolates (ca.

    Article Title: Bio-inspired synthesis yields a tricyclic indoline that selectively resensitizes methicillin-resistant Staphylococcus aureus (MRSA) to ?-lactam antibiotics
    Article Snippet: With this highly diverse and functionalized indoline library in hand, we next screened their ability to potentiate the activity of methicillin in MRSA.With this highly diverse and functionalized indoline library in hand, we next screened their ability to potentiate the activity of methicillin in MRSA.. A multidrug-resistant MRSA strain [American Type Culture Collection (ATCC): BAA-44] was selected for the initial screening.. In addition to methicillin, this MRSA strain is also resistant to many other β-lactam antibiotics, as well as antibiotics from other structural classes, such as erythromycin, tetracycline, and ciprofloxacin.In addition to methicillin, this MRSA strain is also resistant to many other β-lactam antibiotics, as well as antibiotics from other structural classes, such as erythromycin, tetracycline, and ciprofloxacin.

    Membrane:

    Article Title: Photoactivated 2,3-Distyrylindoles Kill Multi-Drug Resistant Bacteria
    Article Snippet: To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.. 28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.. 28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.

    Article Title: Photoactivated 2,3-Distyrylindoles Kill Multi-Drug Resistant Bacteria
    Article Snippet: Herein, we describe these recent findings by showing that 1 and its structural analogues represent significant promise as light-activated antimicrobial agents active against resistant Gram-positive and Gram-negative strains, including those that pose the greatest risk to human health as identified by the WHO, as discussed above. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Previously synthesized 2,3-distyrylindole 1 .significant promise as light-activated antimicrobial agents active against resistant Gram-positive and Gram-negative strains, including those that pose the greatest risk to human health as identified by the WHO, as discussed above. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Previously synthesized 2,3-distyrylindole 1 . ... Our initial experimentation involved the utilization of a multidrug resistant MRSA strain (ATCC BAA-44, HA-MRSA), a clinical isolate from a hospital in Lisbon, Portugal.. In addition to beta-lactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.In addition to beta-lactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.

    Article Title: Photoactivated 2,3-Distyrylindoles Kill Multi-Drug Resistant Bacteria
    Article Snippet: To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.. The panel included: another multidrug-resistant MRSA strain (ATCC BAA1717, CA-MRSA); drug-sensitive Staphylococcus aureus ; vancomycin-resistant Enterococcus faecalis , known as VRE and representing another bacterial genus on the WHO list as discussed above; 26 Streptococcus pyogenes , a causative agent of important human diseases, ranging from superficial skin infections to life-threatening systemic infections; 27 Streptococcus mutans , a species commonly found in human oral cavity and the main contributor to tooth decay.. 28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into..

    Article Title: Photoactivated 2,3-distyrylindoles kill multi-drug resistant bacteria
    Article Snippet: To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA44), we performed experiments with other Gram-positive bacterial strains.not limited to HA-MRSA (ATCC BAA44), we performed experiments with other Gram-positive bacterial strains. ... The panel included: another multidrug-resistant MRSA strain (ATCC BAA1717, CA-MRSA); drug-sensitive Staphylococcus aureus; vancomycin-resistant Enterococcus faecalis, known as VRE and representing another bacterial genus on the WHO list as discussed above;26 Streptococcus pyogenes, a causative agent of important human diseases, ranging from superficial skin infections to life-threatening systemic infections;27 Streptococcus mutans, a species commonly found in human oral cavity and the main contributor to tooth decay.28 The latter organism is of particular interest due to its resistance to various classes of antibiotics29 and the convenience of light delivery into the oral cavity.. As can be seen in Figure 4, all these Gram-positive organisms are sensitive to the bactericidal effects of 1.As can be seen in Figure 4, all these Gram-positive organisms are sensitive to..

    Article Title: Photoactivated 2,3-distyrylindoles kill multi-drug resistant bacteria
    Article Snippet: Previously synthesized 2,3-distyrylindole 1.Previously synthesized 2,3-distyrylindole 1.. Our initial experimentation involved the utilization of a multidrug resistant MRSA strain (ATCC BAA-44, HA-MRSA), a clinical isolate from a hospital in Lisbon, Portugal.. In addition to betalactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.23,24 Thus, the bacterial isolates (ca.In addition to betalactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.23,24 Thus, the bacterial isolates (ca.

    Article Title: Bio-inspired synthesis yields a tricyclic indoline that selectively resensitizes methicillin-resistant Staphylococcus aureus (MRSA) to ?-lactam antibiotics
    Article Snippet: With this highly diverse and functionalized indoline library in hand, we next screened their ability to potentiate the activity of methicillin in MRSA.With this highly diverse and functionalized indoline library in hand, we next screened their ability to potentiate the activity of methicillin in MRSA.. A multidrug-resistant MRSA strain [American Type Culture Collection (ATCC): BAA-44] was selected for the initial screening.. In addition to methicillin, this MRSA strain is also resistant to many other β-lactam antibiotics, as well as antibiotics from other structural classes, such as erythromycin, tetracycline, and ciprofloxacin.In addition to methicillin, this MRSA strain is also resistant to many other β-lactam antibiotics, as well as antibiotics from other structural classes, such as erythromycin, tetracycline, and ciprofloxacin.

    Fluorescence:

    Article Title: Photoactivated 2,3-Distyrylindoles Kill Multi-Drug Resistant Bacteria
    Article Snippet: To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.. 28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.. 28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.

    Article Title: Photoactivated 2,3-Distyrylindoles Kill Multi-Drug Resistant Bacteria
    Article Snippet: Herein, we describe these recent findings by showing that 1 and its structural analogues represent significant promise as light-activated antimicrobial agents active against resistant Gram-positive and Gram-negative strains, including those that pose the greatest risk to human health as identified by the WHO, as discussed above. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Previously synthesized 2,3-distyrylindole 1 .significant promise as light-activated antimicrobial agents active against resistant Gram-positive and Gram-negative strains, including those that pose the greatest risk to human health as identified by the WHO, as discussed above. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Previously synthesized 2,3-distyrylindole 1 . ... Our initial experimentation involved the utilization of a multidrug resistant MRSA strain (ATCC BAA-44, HA-MRSA), a clinical isolate from a hospital in Lisbon, Portugal.. In addition to beta-lactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.In addition to beta-lactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.

    Article Title: Photoactivated 2,3-Distyrylindoles Kill Multi-Drug Resistant Bacteria
    Article Snippet: To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.. The panel included: another multidrug-resistant MRSA strain (ATCC BAA1717, CA-MRSA); drug-sensitive Staphylococcus aureus ; vancomycin-resistant Enterococcus faecalis , known as VRE and representing another bacterial genus on the WHO list as discussed above; 26 Streptococcus pyogenes , a causative agent of important human diseases, ranging from superficial skin infections to life-threatening systemic infections; 27 Streptococcus mutans , a species commonly found in human oral cavity and the main contributor to tooth decay.. 28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into..

    Article Title: Photoactivated 2,3-distyrylindoles kill multi-drug resistant bacteria
    Article Snippet: To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA44), we performed experiments with other Gram-positive bacterial strains.not limited to HA-MRSA (ATCC BAA44), we performed experiments with other Gram-positive bacterial strains. ... The panel included: another multidrug-resistant MRSA strain (ATCC BAA1717, CA-MRSA); drug-sensitive Staphylococcus aureus; vancomycin-resistant Enterococcus faecalis, known as VRE and representing another bacterial genus on the WHO list as discussed above;26 Streptococcus pyogenes, a causative agent of important human diseases, ranging from superficial skin infections to life-threatening systemic infections;27 Streptococcus mutans, a species commonly found in human oral cavity and the main contributor to tooth decay.28 The latter organism is of particular interest due to its resistance to various classes of antibiotics29 and the convenience of light delivery into the oral cavity.. As can be seen in Figure 4, all these Gram-positive organisms are sensitive to the bactericidal effects of 1.As can be seen in Figure 4, all these Gram-positive organisms are sensitive to..

    Article Title: Photoactivated 2,3-distyrylindoles kill multi-drug resistant bacteria
    Article Snippet: Previously synthesized 2,3-distyrylindole 1.Previously synthesized 2,3-distyrylindole 1.. Our initial experimentation involved the utilization of a multidrug resistant MRSA strain (ATCC BAA-44, HA-MRSA), a clinical isolate from a hospital in Lisbon, Portugal.. In addition to betalactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.23,24 Thus, the bacterial isolates (ca.In addition to betalactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.23,24 Thus, the bacterial isolates (ca.

    Article Title: Bio-inspired synthesis yields a tricyclic indoline that selectively resensitizes methicillin-resistant Staphylococcus aureus (MRSA) to ?-lactam antibiotics
    Article Snippet: With this highly diverse and functionalized indoline library in hand, we next screened their ability to potentiate the activity of methicillin in MRSA.With this highly diverse and functionalized indoline library in hand, we next screened their ability to potentiate the activity of methicillin in MRSA.. A multidrug-resistant MRSA strain [American Type Culture Collection (ATCC): BAA-44] was selected for the initial screening.. In addition to methicillin, this MRSA strain is also resistant to many other β-lactam antibiotics, as well as antibiotics from other structural classes, such as erythromycin, tetracycline, and ciprofloxacin.In addition to methicillin, this MRSA strain is also resistant to many other β-lactam antibiotics, as well as antibiotics from other structural classes, such as erythromycin, tetracycline, and ciprofloxacin.

    Disruption:

    Article Title: Photoactivated 2,3-Distyrylindoles Kill Multi-Drug Resistant Bacteria
    Article Snippet: To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.. 28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.. 28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.

    Article Title: Photoactivated 2,3-Distyrylindoles Kill Multi-Drug Resistant Bacteria
    Article Snippet: Herein, we describe these recent findings by showing that 1 and its structural analogues represent significant promise as light-activated antimicrobial agents active against resistant Gram-positive and Gram-negative strains, including those that pose the greatest risk to human health as identified by the WHO, as discussed above. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Previously synthesized 2,3-distyrylindole 1 .significant promise as light-activated antimicrobial agents active against resistant Gram-positive and Gram-negative strains, including those that pose the greatest risk to human health as identified by the WHO, as discussed above. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Previously synthesized 2,3-distyrylindole 1 . ... Our initial experimentation involved the utilization of a multidrug resistant MRSA strain (ATCC BAA-44, HA-MRSA), a clinical isolate from a hospital in Lisbon, Portugal.. In addition to beta-lactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.In addition to beta-lactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.

    Article Title: Photoactivated 2,3-Distyrylindoles Kill Multi-Drug Resistant Bacteria
    Article Snippet: To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA-44), we performed experiments with other Gram-positive bacterial strains.. The panel included: another multidrug-resistant MRSA strain (ATCC BAA1717, CA-MRSA); drug-sensitive Staphylococcus aureus ; vancomycin-resistant Enterococcus faecalis , known as VRE and representing another bacterial genus on the WHO list as discussed above; 26 Streptococcus pyogenes , a causative agent of important human diseases, ranging from superficial skin infections to life-threatening systemic infections; 27 Streptococcus mutans , a species commonly found in human oral cavity and the main contributor to tooth decay.. 28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into the oral cavity.28 The latter organism is of particular interest due to its resistance to various classes of antibiotics 29 and the convenience of light delivery into..

    Article Title: Photoactivated 2,3-distyrylindoles kill multi-drug resistant bacteria
    Article Snippet: To investigate whether the bactericidal effect of 1 was not limited to HA-MRSA (ATCC BAA44), we performed experiments with other Gram-positive bacterial strains.not limited to HA-MRSA (ATCC BAA44), we performed experiments with other Gram-positive bacterial strains. ... The panel included: another multidrug-resistant MRSA strain (ATCC BAA1717, CA-MRSA); drug-sensitive Staphylococcus aureus; vancomycin-resistant Enterococcus faecalis, known as VRE and representing another bacterial genus on the WHO list as discussed above;26 Streptococcus pyogenes, a causative agent of important human diseases, ranging from superficial skin infections to life-threatening systemic infections;27 Streptococcus mutans, a species commonly found in human oral cavity and the main contributor to tooth decay.28 The latter organism is of particular interest due to its resistance to various classes of antibiotics29 and the convenience of light delivery into the oral cavity.. As can be seen in Figure 4, all these Gram-positive organisms are sensitive to the bactericidal effects of 1.As can be seen in Figure 4, all these Gram-positive organisms are sensitive to..

    Article Title: Photoactivated 2,3-distyrylindoles kill multi-drug resistant bacteria
    Article Snippet: Previously synthesized 2,3-distyrylindole 1.Previously synthesized 2,3-distyrylindole 1.. Our initial experimentation involved the utilization of a multidrug resistant MRSA strain (ATCC BAA-44, HA-MRSA), a clinical isolate from a hospital in Lisbon, Portugal.. In addition to betalactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.23,24 Thus, the bacterial isolates (ca.In addition to betalactams, this strain is resistant to antibiotics of many other structural and mechanistic types, such as erythromycin, tetracycline, ciprofloxacin, tobramycin.23,24 Thus, the bacterial isolates (ca.

    Article Title: Bio-inspired synthesis yields a tricyclic indoline that selectively resensitizes methicillin-resistant Staphylococcus aureus (MRSA) to ?-lactam antibiotics
    Article Snippet: With this highly diverse and functionalized indoline library in hand, we next screened their ability to potentiate the activity of methicillin in MRSA.With this highly diverse and functionalized indoline library in hand, we next screened their ability to potentiate the activity of methicillin in MRSA.. A multidrug-resistant MRSA strain [American Type Culture Collection (ATCC): BAA-44] was selected for the initial screening.. In addition to methicillin, this MRSA strain is also resistant to many other β-lactam antibiotics, as well as antibiotics from other structural classes, such as erythromycin, tetracycline, and ciprofloxacin.In addition to methicillin, this MRSA strain is also resistant to many other β-lactam antibiotics, as well as antibiotics from other structural classes, such as erythromycin, tetracycline, and ciprofloxacin.



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